APBN New Site

APBN Developing Site

New Screening Method for Early Diagnosis of Liver Cancer in Hepatitis B Carriers

New method expected to be more convenient and non-invasive to identify early stage liver cancer.

Chinese scientists have designed a new screening method for hepatitis B carriers, to detect early-stage hepatocellular carcinoma (HCC), the most common type of primary liver cancer.

The new method was developed by researchers from Cancer Hospital, Chinese Academy of Medical Sciences and Genetron Health, a biomedical company. Through a liquid biopsy that detects cell-free DNA somatic mutations in combination with protein markers, researchers can efficiently identify early-stage HCC cases of less than 3 cm.

According to one of the researchers, the method showed 100 percent sensitivity, 94 percent specificity and 17 percent positive predictive value in the validation cohort, proving it a feasible approach to identify early stage HCC.

The research team will optimise this screening method through systematic research in a multi-center, large prospective cohort study.

After rigorous clinical validation, this method is expected to become a more convenient, non-invasive and standardised early screening program for liver cancer.

The research was published in the Proceedings of the National Academy of Sciences USA. [APBN]

Source: China Daily