APBN New Site

APBN Developing Site

Mesh Bio and MultiOmic Health Partner to Use AI to Develop Precision Medicines and Diagnostics for Chronic Metabolic Disease

This partnership will enable both companies to progress their respective R&D programmes to develop precision therapeutic and diagnostic products, transforming the lives of patients with metabolic syndrome-related conditions.

Singapore-based Mesh Bio, a digital health startup transforming chronic disease management through predictive analytics, and UK-based artificial intelligence (AI)-enabled drug discovery company MultiOmic Health announced in June their partnership to conduct an observational clinical study on patients with chronic metabolic disease and increased risk of complications such as chronic kidney disease. The partnership will provide access to data from patient populations in Asia, that have historically been underrepresented in chronic metabolic disease studies.

Mesh will collaborate with its network of healthcare provider customers to recruit patients for the study. MultiOmic will generate genomic, proteomic, metabolomic, and potentially other omics data from anonymised body fluid samples. These will be combined with anonymised data from clinical and diagnostic tests for both companies to build a rich multi-omics dataset and derive AI-based computational biology models.

The study will enable MultiOmic and Mesh to progress their respective R&D programmes to develop precision therapeutic and diagnostic products that will transform the lives of patients with metabolic syndrome-related conditions. They will also jointly conduct collaborative projects to enhance patient stratification for other biopharma and MedTech companies’ clinical-stage R&D programmes.

Metabolic syndrome-related conditions such as type 2 diabetes mellitus (T2D), chronic kidney disease (CKD), atherosclerotic cardiovascular disease (ASCVD), non-alcoholic fatty liver disease (NAFLD) and polycystic ovarian syndrome (PCOS) arise from a common set of risk factors present in half the world’s adult population. These age-related conditions can lead to serious consequences, including heart attack, stroke, blindness, nerve damage, foot amputation, kidney dialysis, and liver failure. Prior to the COVID-19 pandemic, they accounted for half the world’s deaths and nearly US$ 2 trillion in global healthcare spending.

This burden will be further exacerbated by the pandemic. A significant proportion of COVID-related hospitalisations and fatalities arose in patients with metabolic syndrome conditions and recent studies have indicated that COVID survivors have an increased risk of being diagnosed with T2D and CKD.

“Longitudinal multi-omics data combined with deep clinical phenotyping is essential to developing transformative therapeutics and diagnostics in chronic multi-factorial diseases,” said Angeli Möller, PhD, Vice-Chairperson and co-founder of the Alliance for Artificial Intelligence in Healthcare, the global advocacy organization for applying AI solutions to improve patient lives. “In contrast to most of the historical research for these diseases that [have] relied on Caucasian patients, this partnership will generate new and much-needed insights specific to populations in Asia.”

“Mesh Bio is committed to driving precision clinical interventions in the management of chronic metabolic disease, in order to improve patient outcomes. Our vision is for holistic patient assessment, powered by analytics on fullstack biology.” said Andrew Wu, PhD, Co-Founder and CEO of Mesh. “We are delighted to partner with MultiOmic Health on this important study for patients in Asia. Their therapeutic development programs for metabolic disease intervention have deep synergies with Mesh Bio’s mission to develop digital care delivery solutions for these diseases.”

“This partnership gives us access to a population base in Asia exhibiting high and increasing prevalence of metabolic syndrome-related conditions,” said Robert Thong, Co-Founder and CEO of MultiOmic. “We are delighted to collaborate with Mesh Bio as a like-minded and capable strategic partner working with healthcare providers that have many patients in our target chronic medical conditions. Our product development programmes and technical teams also complement each other.” [APBN]

Source: Mesh Bio and MultiOmic Health