APBN New Site

APBN Developing Site

Agreement Signed for Production of Anti-VISTA Antibody for Cancer Clinical Trial

Innovative biotherapeutics company, Hummingbird Bioscience announced a partnership with Mycenax Biotech to produce anti-VISTA antibody, HMBD-002 for use in Phase I clinical trials of its HMBD-002 program.

HMBD-002 is an anti-VISTA antibody developed for solid tumors that are unresponsive to existing treatments. VISTA is a new and important target for cancer as it strongly suppresses the activation of the body’s anti-tumor immune response. The presence of VISTA cells is frequently associated with the emergence of tumors and resistance to current cancer immunotherapies.

Hummingbird Bioscience, announced on 20 February 2020 that its has signed an agreement with Mycenax Biotech for the production of production of material for the Phase I clinical trial of its HMBD-002 program which is anticipated to commence in the second half of 2020.

“We are very pleased to be working with Mycenax, a pioneering provider of high-quality biologics, for the production of our anti-VISTA antibody, HMBD-002. This contract takes us one step closer to realizing the goal of more effective immunotherapies for a broader population of individuals with cancer,” said Dr Jerome Boyd-Kirkup, Chief Scientific Officer and co-founder, Hummingbird Bioscience.

HMBD-002 uniquely blocks VISTA’s activation, turning off the signal that keeps immune cells dormant. Critically, unlike other investigational anti-VISTA agents, HMBD-002 does not remove VISTA expressing cells from the body, thus allowing many of these cells to become active tumor-killing cells. Pre-clinical studies have shown that HMBD-002 can strongly inhibit tumor growth, both as a monotherapy and even more potently when combined with anti-PD(L)1 treatment.

“We think HMBD-002 has great therapeutic potential and we are honored and excited to work with Hummingbird Bioscience on this project. We are committed to providing professional and customized service to facilitate the progress of the project. We are optimistic that, with our expertise and capability in CMC and production, HMBD-002 will be able to enter clinical trials and show therapeutic benefits soon,” said Dr Pei-Jiun Chen, CEO and President of Mycenax. [APBN]